(+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine

Base Information

• Chemical Name: (+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine
• CAS No.: 177587-23-4
• Molecular Formula: C₂₇H₃₉NO₄
• Molecular Weight: 441.611
• Mol file: 177587-23-4.mol

Synonyms:(+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine

Chemical Property of (+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine

There total 4 articles about (+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid (177587-71-2) + tert-butyl alcohol (75-65-0) → (+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine (177587-23-4)

Guidance literature:

(+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid; With diphenyl phosphoryl azide; triethylamine; In benzene; for 2h; Heating;

tert-butyl alcohol; for 20h; Heating;

DOI:10.1021/jm990135j

Reference yield:

ethyl 3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylacrylate → (+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine (177587-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: H₂ / 5 percent Pd/C / ethanol

2.1: 99 percent / aq. KOH / ethanol

3.1: diphenyl phosphorazidate, Et₃N / benzene / 2 h / Heating

3.2: 64 percent / 20 h / Heating

With potassium hydroxide; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; benzene; 1.1: Hydrogenation / 2.1: Hydrolysis / 3.1: modified Curtius reaction / 3.2: Alkylation;

DOI:10.1021/jm990135j

Reference yield:

ethyl 3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionate (177587-70-1) → (+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine (177587-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 99 percent / aq. KOH / ethanol

2.1: diphenyl phosphorazidate, Et₃N / benzene / 2 h / Heating

2.2: 64 percent / 20 h / Heating

With potassium hydroxide; diphenyl phosphoryl azide; triethylamine; In ethanol; benzene; 1.1: Hydrolysis / 2.1: modified Curtius reaction / 2.2: Alkylation;

DOI:10.1021/jm990135j

upstream raw materials:

(+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid

tert-butyl alcohol

ethyl 3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionate