1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-, S,1-dioxide

Base Information

Chemical Name:1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-, S,1-dioxide
CAS No.:74667-83-7
Molecular Formula:C₂₂H₂₈N₂O₅S₂
Molecular Weight:464.607
Hs Code.:
DSSTox Substance ID:DTXSID90996185
Nikkaji Number:J395.332G

Synonyms:BRN 4600229;VUFB-12373;74667-83-7;1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-, S,1-dioxide;DTXSID90996185;C22H28N2O5S2;C22-H28-N2-O5-S2;LS-113334;1-Piperazinepropanol,4-[10,11-dihydro-8-(methylsulfonyl)-5-oxidodibenzo[b,f]thiepin-10-yl]-,1-oxide;10-[[4-(3-Hydroxypropyl)piperazine 4-oxide]-1-yl]-8-(methylsulfonyl)-10,11-dihydrodibenzo[b,f]thiepin 5-oxide;11-[4-(3-Hydroxypropyl)-4-oxo-4lambda~5~-piperazin-1-yl]-2-(methanesulfonyl)-10,11-dihydro-5H-5lambda~4~-dibenzo[b,f]thiepin-5-one

Suppliers and Price of 1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-, S,1-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-, S,1-dioxide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:g/cm³
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:464.14396435
Heavy Atom Count:31
Complexity:748

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)C1=CC2=C(C=C1)S(=O)C3=CC=CC=C3CC2N4CC[N+](CC4)(CCCO)[O-]

Technology Process of 1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-, S,1-dioxide

There total 4 articles about 1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-, S,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 74667-79-1
10-<4-(3-hydroxypropyl)piperazino>-8-methylsulfonyl-10,11-dihydrodibenzothiepin S-⁵-oxide

: 74667-83-7
10-<4-(3-hydroxypropyl)piperazino>-8-methylsulfonyl-10,11-dihydrodibenzothiepin N⁴,S⁵-dioxide

Guidance literature:: With dihydrogen peroxide; In ethanol; water; 1) 75 deg C; 2) 48 h, room temp.;
DOI:10.1135/cccc19800529

Reference yield:

: 5317-32-8
3-(1-piperazinyl)-1-propanol

: 74667-83-7
10-<4-(3-hydroxypropyl)piperazino>-8-methylsulfonyl-10,11-dihydrodibenzothiepin N⁴,S⁵-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / CHCl₃ / 14 h / Heating

2: methanesulfonic acid, 30percent H₂O₂ / H₂O / 40 h / Ambient temperature

3: 84 percent / 29percent H₂O₂ / ethanol; H₂O / 1) 75 deg C; 2) 48 h, room temp.

With methanesulfonic acid; dihydrogen peroxide; In ethanol; chloroform; water;
DOI:10.1135/cccc19800529

Reference yield:

: 16185-20-9
10-chloro-8-methylsulfonyl-10,11-dihydrodibenzothiepin

: 74667-83-7
10-<4-(3-hydroxypropyl)piperazino>-8-methylsulfonyl-10,11-dihydrodibenzothiepin N⁴,S⁵-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / CHCl₃ / 14 h / Heating

2: methanesulfonic acid, 30percent H₂O₂ / H₂O / 40 h / Ambient temperature

3: 84 percent / 29percent H₂O₂ / ethanol; H₂O / 1) 75 deg C; 2) 48 h, room temp.

With methanesulfonic acid; dihydrogen peroxide; In ethanol; chloroform; water;
DOI:10.1135/cccc19800529