5317-32-8

Basic information

• Product Name: 1-Piperazinepropanol
• Synonyms: 1-(3-HYDROXYPROPYL)-PIPERAZINE;1-PIPERAZINEPROPANOL;3-PIPERAZIN-1-YLPROPAN-1-OL;piperazin-1-ylpropan-ol;1-(3-HYDROXYPROPYL)-PIPERAZINE >98%;1-Piperazine-1-propanol;1-Piperazinepropanol,98%;1-(3-Hydroxy-1-propyl)piperazine
• CAS NO: 5317-32-8
• Molecular Formula: C₇H₁₆N₂O
• Molecular Weight: 144.21
• EINECS: 226-176-0
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 5317-32-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 49-53 °C(lit.)
• Boiling Point: 94-96°C/1.8mm
• Flash Point: >230 °F
• Appearance: white.
• Density: 0.993 g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.481
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.10±0.10(Predicted)
• CAS DataBase Reference: 1-Piperazinepropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinepropanol(5317-32-8)
• EPA Substance Registry System: 1-Piperazinepropanol(5317-32-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 2
• Hazardous Substances Data: 5317-32-8(Hazardous Substances Data)

Usage

Uses

Reactant for preparation of biologically active molecules:Preparation of chloropyridazine piperazines as human rhinovirus (HRV-3) inhibitorsSynthesis of arylbenzoylpyrrolidine derivatives and their Hsp90 inhibitory activitySynthesis of pyrrolothienopyrazines as novel serotonin-4 receptors antagonistsPreparation of carbamate-functionalized 2,6-disubstituted N-(arylsulfonyl) piperidines as conformationally restricted and orally active γ-secretase inhibitors

InChI:InChI=1/C7H16N2O/c1-2-7(10)9-5-3-8-4-6-9/h7-8,10H,2-6H2,1H3

Upstream product

• 110-85-0 piperazine 
• 627-18-9 1-bromo-3-propanol 
• 7483-27-4 4-(3-hydroxypropyl)piperazinylcarboxylic acid ethyl ester 
• 627-32-7 1-iodopropan-3-ol 
• 7755-92-2 piperazine-1-carbaldehyde 
• 210553-81-4 4-(3-hydroxypropyl)-1-piperazinecarboxaldehyde 
• 627-30-5 1-chloro-3-hydroxypropane 
• 13173-24-5 N,N'-bis-allylpiperazine 
• 107-18-6 allyl alcohol 

Downstream Products

• 5317-33-9 3-(4-methyl-1-piperazinyl)-1-propanol 
• 30297-78-0 3-(4-nitroso-piperazin-1-yl)-propan-1-ol 
• 101862-04-8 3-(4-cyanomethylpiperazin-1-yl)propan-1-ol 
• 90096-39-2 1-benzhydryl-4-(3-hydroxypropyl)piperazine 
• 1271943-25-9 3-{4-[3-(4-ethoxylphenoxy)propyl]piperazin-1-yl}-6-chloropyridazine 
• 1271943-27-1 3-{4-[3-(4-methylphenoxy)propyl]piperazin-1-yl}-6-chloropyridazine 
• 1271943-29-3 3-{4-[3-(4-ethylphenoxy)propyl]piperazin-1-yl}-6-chloropyridazine 
• 1271943-31-7 3-{4-[3-(4-isopropylphenoxy)propyl]piperazin-1-yl}-6-chloropyridazine 
• 1271943-33-9 4-{3-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]propoxy}benzoic acid methyl ester 
• 124437-35-0 4-{3-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]propoxy}benzoic acid ethyl ester 
• 1412888-05-1 (3-(4-(1-benzyl)-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl)propanol 
• 1412888-10-8 C₂₄H₂₉N₁₁O₄ 
• 1412888-11-9 1-(3(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl)propyl)-N⁴,N⁵-bis(6-hydroxy-hexyl)-1,2,3-triazole-4,5-dicarboxamide 
• 1412888-12-0 1-(3(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl)propyl)-N⁴,N⁵-bis(cyclopropyl)-1,2,3-triazole-4,5-dicarboxamide 

Relevant articles and documents

2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

Compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

Method for producing N-alkylpiperazine

PROBLEM TO BE SOLVED: To provide a method for producing N-alkyl piperazines in high yield by selectively alkylating one amino group.SOLUTION: In the method for producing N-alkyl piperazines, piperazines represented by general formula (1) are reacted with a specific alkylating agent in the presence of an acid. In the formula: R-Rare each independently a hydrogen atom, a methyl group, an ethyl group, a 3-8C linear alkyl group or the like, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group, a methoxy group, an ethoxy group, a phenyl group, a benzyl group, a 2-phenylethyl group, or the like.

PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION

Disclosed are pyridazine derivatives represented by formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.