2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole

Base Information

• Chemical Name: 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole
• CAS No.: 1394128-62-1
• Molecular Formula: C₁₈H₁₇N₃O₆S₄
• Molecular Weight: 499.613

Synonyms:2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole

Chemical Property of 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole

Chemical Property:

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Technology Process of 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole

There total 1 articles about 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-phenylsulfonylethenesulfonylacetic acid (1155273-85-0) → 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole (1394128-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / Reflux

2: thiourea / tetrahydrofuran / 120 - 150 °C

With thiourea; trichlorophosphate; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2012.06.014

Reference yield: 72.0%

2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole (1394128-62-1) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 2-(phenylaminosulfonylmethyl)-5-(4'-phenylsulfonyl-1'H-pyrrol-3'-ylsulfonyl-methyl)-1,3,4-thiadiazole (1394128-71-2)

Guidance literature:

With sodium hydride; In diethyl ether; dimethyl sulfoxide; at 20 ℃;

DOI:10.1016/j.ejmech.2012.06.014

Reference yield: 69.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole (1394128-62-1) → 2-(phenylaminosulfonylmethyl)-5-(3'-phenylsulfonyl-4',5'-dihydro-1'H-pyrazol-4'-ylsulfonylmethyl)-1,3,4-thiadiazole (1394128-80-3)

Guidance literature:

In diethyl ether; dichloromethane; at -20 - -15 ℃; for 48h;

DOI:10.1016/j.ejmech.2012.06.014

upstream raw materials:

(E)-phenylsulfonylethenesulfonylacetic acid

Downstream raw materials:

2-(phenylaminosulfonylmethyl)-5-(3'-phenylsulfonyl-4',5'-dihydro-1'H-pyrazol-4'-ylsulfonylmethyl)-1,3,4-thiadiazole

2-(phenylaminosulfonylmethyl)-5-(4'-phenylsulfonyl-1'H-pyrrol-3'-ylsulfonyl-methyl)-1,3,4-thiadiazole

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