4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid

Base Information

Chemical Name:4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid
CAS No.:138812-91-6
Molecular Formula:C₂₉H₅₁IO₉Si₂
Molecular Weight:726.794
Hs Code.:

Synonyms:4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid

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Chemical Property of 4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid

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Technology Process of 4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid

There total 26 articles about 4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 168567-07-5
4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzaldehyde

: 138812-91-6
4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 138812-91-6
4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine, DMAP / CH₂Cl₂ / 36 h / Ambient temperature

2: 77 percent / i-Bu₂AlH / hexane; toluene / 0 °C

3: 98 percent / NaH₂PO₄*H₂O, NaClO₂, 2-methyl-2-butene / butan-1-ol / 0.5 h / Ambient temperature

With pyridine; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diisobutylaluminium hydride; In hexane; dichloromethane; toluene; butan-1-ol;
DOI:10.1021/ja00126a013

Reference yield:

: 138785-37-2
methyl 4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoate

: 138812-91-6
4-<(6-deoxy-2,4-O,O-bis<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / DIBAL-H / CH₂Cl₂; cyclohexane / 0.33 h / -78 °C

2: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 °C

3: 98 percent / NaH₂PO₄*H₂O, NaClO₂, 2-methyl-2-butene / butan-1-ol / 0.5 h / Ambient temperature

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diisobutylaluminium hydride; Dess-Martin periodane; In dichloromethane; cyclohexane; butan-1-ol;
DOI:10.1021/ja00126a013