5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole

Base Information

Chemical Name:5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole
CAS No.:1372151-20-6
Molecular Formula:C₂₀H₂₃N₅O₃
Molecular Weight:381.434
Hs Code.:

Synonyms:5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole

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Chemical Property of 5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole

Chemical Property:

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Technology Process of 5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole

There total 5 articles about 5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255208-69-5
1-[2-(4-nitrophenyl)ethyl]piperazine hydrochloride

: 1279109-01-1
2,1,3-benzoxadiazol-5-ylacetaldehyde

: 1372151-20-6
5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole

Guidance literature:: With titanium(IV) isopropylate; sodium cyanoborohydride; acetic acid; In ethanol; at 20 ℃; for 16h;

Reference yield:

: 130636-60-1
4-[2-(4-nitro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

: 1372151-20-6
5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h

2: sodium cyanoborohydride; acetic acid; titanium(IV) isopropylate / ethanol / 16 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; sodium cyanoborohydride; acetic acid; In 1,4-dioxane; ethanol;

Reference yield:

: 51376-06-8
5-bromo-benzo[1,2,5]oxadiazole

: 1372151-20-6
5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / toluene / 3 h / Inert atmosphere; Reflux

2: ozone / dichloromethane / 2 h / -78 - 20 °C

3: sodium cyanoborohydride; acetic acid; titanium(IV) isopropylate / ethanol / 16 h / 20 °C

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; ozone; acetic acid; lithium chloride; In ethanol; dichloromethane; toluene;