130636-60-1

Usage

InChI:InChI=1/C17H25N3O4/c1-17(2,3)24-16(21)19-12-10-18(11-13-19)9-8-14-4-6-15(7-5-14)20(22)23/h4-7H,8-13H2,1-3H3

Upstream product

• 110-85-0 piperazine 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 91098-69-0 1-[2-(4-nitrophenyl)ethyl]piperazine 
• 329004-08-2 tert-butyl 4-(4-aminophenethyl)piperazine-1-carboxylate 
• 1372151-32-0 1-[2-(4-nitrophenyl)ethyl]-4-[2-(4-nitrophenyl)propyl]piperazine 
• 1374357-26-2 5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2-benzofuran-1(3H)-one 
• 1372151-16-0 1,4-bis[2-(4-nitrophenyl)ethyl]piperazine 
• 1372151-33-1 1-[1-methyl-2-(4-nitrophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine 
• 1372151-20-6 5-(2-{4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl}ethyl)-2,1,3-benzoxadiazole 
• 1255208-69-5 1-[2-(4-nitrophenyl)ethyl]piperazine hydrochloride 
• 329004-09-3 4-[2-(4-methanesulfonylamino-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 136188-94-8 1-[2-(4-methanesulfonamidophenyl)ethyl]piperazine 

Relevant academic research and scientific papers

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

no abstract published

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure

Synthesis and class III type antiarrhythmic activity of 4-Aroyl (and Aryl)-1-aralkylpiperazines

The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1-aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC20 of 3 nM, ranks as one of the most potent (in vitro) compounds reported. (C) 2000 Elsevier Science Ltd.

Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same

A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.