3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

Base Information

Chemical Name:3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester
CAS No.:910046-61-6
Molecular Formula:C₂₅H₄₂O₅SSi
Molecular Weight:482.757
Hs Code.:

3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid <i>S</i>-<i>tert</i>-butyl ester

Synonyms:3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

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Chemical Property of 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

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Technology Process of 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

There total 3 articles about 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910046-73-0
(3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

: 910046-61-6
3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

Guidance literature:: (3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester; With ozone; In dichloromethane; at -78 ℃; for 0.00833333h;

With triphenylphosphine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol061173h

Reference yield:

: 910046-60-5
(3R,5S)-3-hydroxy-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

: 910046-61-6
3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

2.1: O₃ / CH₂Cl₂ / 0.01 h / -78 °C

2.2: PPh₃ / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; ozone; In dichloromethane;
DOI:10.1021/ol061173h

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 910046-61-6
3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

2.1: O₃ / CH₂Cl₂ / 0.01 h / -78 °C

2.2: PPh₃ / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; ozone; In dichloromethane;
DOI:10.1021/ol061173h