2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester
CAS No.:1370017-99-4
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

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Chemical Property of 2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

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Technology Process of 2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

There total 1 articles about 2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 85908-96-9
2-oxopiperidine-1-carboxylic acid tert-butyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 1370017-99-4
2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

Guidance literature:: 2-oxopiperidine-1-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

benzyl chloroformate; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.120

Reference yield: 97.0%

: 1370017-99-4
2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

: 2-oxopiperidine-3-carboxylic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 1370017-99-4
2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

: 1370018-18-0
tert-butyl 3-(benzyl(phenyl)carbamoyl)-2-oxopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 2 h

2: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; 2-chloro-1-methyl-pyridinium iodide; hydrogen; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2012.01.120