tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate
CAS No.:1370018-19-1
Molecular Formula:C₁₈H₂₃ClN₂O₄
Molecular Weight:366.845
Hs Code.:

Synonyms:tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate

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Chemical Property of tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate

There total 3 articles about tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-96-7
N-methyl(p-chloroaniline)

: 1370018-17-9
1-(tert-butoxycarbonyl)-2-oxopiperidine-3-carboxylic acid

: 1370018-19-1
tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.120

Reference yield:

: 1370017-99-4
2-oxopiperidine-1,3-dicarboxylic acid 3-benzyl ester 1-tert-butyl ester

: 1370018-19-1
tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 2 h

2: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; 2-chloro-1-methyl-pyridinium iodide; hydrogen; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2012.01.120

Reference yield:

: 85908-96-9
2-oxopiperidine-1-carboxylic acid tert-butyl ester

: 1370018-19-1
tert-butyl 3-((4-chlorophenyl)(methyl)carbamoyl)-2-oxopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 2 h

3.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; 2-chloro-1-methyl-pyridinium iodide; hydrogen; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2012.01.120