tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate

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Chemical Name:tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate
CAS No.:1141475-65-1
Molecular Formula:C₃₂H₃₇N₃O₄
Molecular Weight:527.663
Hs Code.:

Synonyms:tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate

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Chemical Property of tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate

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Technology Process of tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate

There total 10 articles about tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1141475-66-2
2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl chloride

: 1141474-44-3
tert-butyl 3-[{3-[amino(hydroxyimino)methyl]benzyl}(methyl)amino]propanoate

: 1141475-65-1
tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate

Guidance literature:: 2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl chloride; tert-butyl 3-[{3-[amino(hydroxyimino)methyl]benzyl}(methyl)amino]propanoate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1.5h;

In acetonitrile; at 150 ℃; for 0.5h; Microwave;

Reference yield:

: 28188-41-2
m-(bromomethyl)benzonitrile

: 1141475-65-1
tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 15 h / 20 °C

2: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 0 - 20 °C / Inert atmosphere

4: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With hydroxylamine hydrochloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557

Reference yield:

: 1141474-45-4
tert-butyl 3-[(3-cyanobenzyl)(methyl)amino]propanoate

: 1141475-65-1
tert-butyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methyl-beta-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 0 - 20 °C / Inert atmosphere

3: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557