28188-41-2Relevant articles and documents
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Ipatieff et al.
, p. 272,284 (1952)
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INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
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Paragraph 00488, (2020/06/10)
The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
NCO-chelated organoantimony(III) and organobismuth(III) dichlorides: Syntheses and structures
Vrana, Jan,Jambor, Roman,Ruzicka, Ales,Holecek, Jaroslav,Dostal, Libor
experimental part, p. 1041 - 1050 (2011/08/09)
The novel NCO chelating ligand L, 1-CH2N(CH3) 2-3-CH2OCH3-C6H4, was prepared in four steps from commercially available m-tolunitrile in a good yield. Successful lithiation of this ligand was achieved by the reaction with n-BuLi in hexane. Using of this in situ prepared organolithium compound LLi in the reactions with MCl3 (M = Sb, Bi) in 1:1 molar ratio led to isolation of the desired mono-organocompounds MLCl2 (M = Sb (1), Bi (2)). Their structures were studied both in solution (NMR) and in the solid state (X-ray diffraction), and were compared with those of the NCN- and OCO-chelating analogues.
BIPHENYL DERIVATIVES
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, (2008/06/13)
Novel compounds of the formula I in which X, R 1, R 2, R 3, R 4 and R 5 have the meaning indicated in Patent Claim 1, are inhibitors of the coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
