3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

Base Information

• Chemical Name: 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester
• CAS No.: 138129-28-9
• Molecular Formula: C₂₁H₁₇BrF₃N₃O₃S
• Molecular Weight: 528.349

Synonyms:3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

Chemical Property of 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

Chemical Property:

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Technology Process of 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

There total 4 articles about 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester (138129-23-4) → 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester (138129-28-9)

Guidance literature:

With tetraphosphorus decasulfide; In benzene; at 70 ℃; for 4h;

DOI:10.1021/jm00105a018

Reference yield:

2'-bromo-5'-trifluoromethyl-2-chloroacetanilide (157097-00-2) → 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester (138129-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

2: P₂S₅ / benzene / 3 h / 70 °C

With tetraphosphorus decasulfide; potassium tert-butylate; In benzene;

DOI:10.1021/jm00081a006

Reference yield:

ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate (25947-13-1) → 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester (138129-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

2: P₂S₅ / benzene / 3 h / 70 °C

With tetraphosphorus decasulfide; potassium tert-butylate; In benzene;

DOI:10.1021/jm00081a006

upstream raw materials:

3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

2'-bromo-5'-trifluoromethyl-2-chloroacetanilide

ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate

Downstream raw materials:

3-[2-[N-[2-Bromo-5-(trifluoromethyl)-phenyl]amino]-2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazinacetic acid

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