3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

Base Information

Chemical Name:3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester
CAS No.:138129-23-4
Molecular Formula:C₂₁H₁₇BrF₃N₃O₄
Molecular Weight:512.283
Hs Code.:

Synonyms:3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

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Chemical Property of 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

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Technology Process of 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

There total 1 articles about 3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157097-00-2
2'-bromo-5'-trifluoromethyl-2-chloroacetanilide

: 25947-13-1
ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate

: 138129-23-4
3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;
DOI:10.1021/jm00105a018

Reference yield:

: 138129-23-4
3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

: 138129-28-9
3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]amino]2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

Guidance literature:: With tetraphosphorus decasulfide; In benzene; at 70 ℃; for 4h;
DOI:10.1021/jm00105a018

Reference yield:

: 138129-23-4
3-[2-[N-[2-Bromo-5-(trifluoromethyl)phenyl]-amino]-2-oxoethyl]-3, 4-dihydro-4-oxo-1-phthalazineacetic acid ethyl ester

: 138129-44-9
3-[2-[N-[2-Bromo-5-(trifluoromethyl)-phenyl]amino]-2-thioxoethyl]-3, 4-dihydro-4-oxo-1-phthalazinacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: P₂S₅ / benzene / 3 h / 70 °C

2: aq. KOH

With potassium hydroxide; tetraphosphorus decasulfide; In benzene;
DOI:10.1021/jm00081a006