methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate

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Chemical Name:methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate
CAS No.:373360-02-2
Molecular Formula:C₂₆H₃₂N₄O₈S₃
Molecular Weight:624.76
Hs Code.:

Synonyms:methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate

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Chemical Property of methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate

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Technology Process of methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate

There total 8 articles about methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 340756-75-4
N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide

: 373359-62-7
3-[4-(4-oxopiperidin-1-yl)phenylsulfamoyl]thiophene-2-carboxylic acid methyl ester

: 373360-02-2
methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0968-0896(01)00114-6

Reference yield:

: 170687-82-8
N-{2-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]phenyl}methane sulfonamide

: 373360-02-2
methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaN₃; NaI / dimethylsulfoxide / 120 h

2: 76 percent / ammonium formate / 10 percent Pd/C / methanol

3: 50 percent / NaBH(OAc)3; acetic acid / dimethylformamide / 20 °C

With sodium azide; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; sodium iodide; palladium on activated charcoal; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00114-6

Reference yield:

: 300345-77-1
N-[5-((1S)-2-azido-1-hydroxyethyl)-2-hydroxyphenyl]methanesulfonamide

: 373360-02-2
methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / ammonium formate / 10 percent Pd/C / methanol

2: 50 percent / NaBH(OAc)3; acetic acid / dimethylformamide / 20 °C

With ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00114-6