(R)-N-(2-(benzyloxy)-5-(2-broMo-1-hydroxyethyl)phenyl)MethanesulfonaMide

Base Information

Chemical Name:(R)-N-(2-(benzyloxy)-5-(2-broMo-1-hydroxyethyl)phenyl)MethanesulfonaMide
CAS No.:170687-82-8
Molecular Formula:C16H18BrNO4S
Molecular Weight:400.293
Hs Code.:
Mol file:170687-82-8.mol

Synonyms:(R)-2-Bromo-1-[4-(phenylmethoxy)-3-[(methylsulfonyl)amino]phenyl]-ethanol;N-[2-Benzyloxy-5-((R)-2-bromo-1-hydroxy-ethyl)-phenyl]-methanesulfonamide;N-[2-benzyloxy-5-(2-bromo-(1S)-1-hydroxyethyl)phenyl]methanesulfonamide;(R)-2-bromo-1-[4-(phenylmethoxy)-3-[(methylsulfonyl)amino]phenyl]ethanol;(R)-2-bromo-1-[4-phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethanol;N-{2-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]phenyl}methanesulfonamide;

Suppliers and Price of (R)-N-(2-(benzyloxy)-5-(2-broMo-1-hydroxyethyl)phenyl)MethanesulfonaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(2-(benzyloxy)-5-(2-broMo-1-hydroxyethyl)phenyl)MethanesulfonaMide

Chemical Property:

PSA：84.01000
Density:1.546
LogP:4.21920

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (R)-N-(2-(benzyloxy)-5-(2-broMo-1-hydroxyethyl)phenyl)MethanesulfonaMide

There total 11 articles about (R)-N-(2-(benzyloxy)-5-(2-broMo-1-hydroxyethyl)phenyl)MethanesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 14347-25-2
2-Bromo-1-[4-phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethanone

: 170687-82-8
N-{2-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]phenyl}methane sulfonamide

Guidance literature:: With Trimethyl borate; dimethylsulfide borane complex; (R)-α,α-diphenylprolinol; In tetrahydrofuran; toluene; at -13 ℃; optical yield given as %ee;
DOI:10.1021/op2001904

Reference yield: 88.0%

: 124-63-0
methanesulfonyl chloride

: 333796-54-6
(1R)-1-[3-amino-4-(phenylmethoxy)phenyl]-2-bromoethan-1-ol

: 170687-82-8
N-{2-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]phenyl}methane sulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 5 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm1005989

Reference yield:

: 188690-82-6
(R)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol

: 170687-82-8
N-{2-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]phenyl}methane sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 12 h / 20 - 25 °C / 5175.52 Torr

2: pyridine / tetrahydrofuran / 2 h / 20 °C

With pyridine; platinum(IV) oxide; hydrogen; In tetrahydrofuran;
DOI:10.1021/op2001904