(2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

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Chemical Name:(2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide
CAS No.:1240522-62-6
Molecular Formula:C₂₁H₂₂FN₇O
Molecular Weight:407.45
Hs Code.:

Synonyms:(2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

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Chemical Property of (2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

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Technology Process of (2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

There total 5 articles about (2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1240522-49-9
(S)-2-amino-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

: 590-17-0
cyanomethyl bromide

: 1240522-62-6
(2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃; for 2h;
DOI:10.1021/ml4000854

Reference yield:

: 1240522-47-7
4-(5-amino-1-methyl-1H-pyrazol-3-yl)-N-methylpyridin-2-amine

: 1240522-62-6
(2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 50 °C

1.2: HPLC columh / 0.75 h

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml4000854

Reference yield:

: 41153-30-4,57292-45-2,79561-25-4,129101-25-3
Boc-Phe(p-F)

: 1240522-62-6
(2S)-2-((cyanomethyl)amino)-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 50 °C

1.2: HPLC columh / 0.75 h

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml4000854