5-fluoro-2-propoxyaniline

Base Information

• Chemical Name: 5-fluoro-2-propoxyaniline
• CAS No.: 946774-77-2
• Molecular Formula: C₉H₁₂FNO
• Molecular Weight: 169.199
• Mol file: 946774-77-2.mol

Synonyms:5-fluoro-2-propoxyaniline

Chemical Property of 5-fluoro-2-propoxyaniline

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-2-propoxyaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 5-fluoro-2-propoxyaniline

There total 3 articles about 5-fluoro-2-propoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-fluoro-2-nitro-1-propoxybenzene (1092496-26-8) → 5-fluoro-2-propoxyaniline (946774-77-2)

Guidance literature:

With 5%-palladium/activated carbon; In ethanol; at 20 ℃;

Reference yield:

2-nitro-4-fluorophenol (394-33-2) → 5-fluoro-2-propoxyaniline (946774-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: 5%-palladium/activated carbon / ethanol / 20 °C

With 5%-palladium/activated carbon; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

1,4-difluoro-2-nitrobenzene (364-74-9) → 5-fluoro-2-propoxyaniline (946774-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / 3 h / 20 - 25 °C / Large scale

2: 5%-palladium/activated carbon / ethanol / 20 °C

With 5%-palladium/activated carbon; potassium tert-butylate; In ethanol;

upstream raw materials:

4-fluoro-2-nitro-1-propoxybenzene

2-nitro-4-fluorophenol

1,4-difluoro-2-nitrobenzene

Downstream raw materials:

2,2,2-trifluoro-N-(5-fluoro-2-propoxyphenyl)acetamide

5-[(5-fluoro-2-propoxyphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

5-fluoro-3-(4-methoxyphenyl)-8-propoxy-1H-quinolin-4-one

4,4,4-trifluoro-3-(5-fluoro-2-propoxyphenylamino)buta-2-enoic acid ethyl ester