394-33-2

Basic information

• Product Name: 2-Nitro-4-fluorophenol
• Synonyms: 4-FLUORO-2-NITROPHENOL;4-Fluoro-2-nitrophenol 99%;4-Fluoro-2-nitrophenol99%;4-fluoro-2-nitrobenzophenol;4-FLUORO-2-NITROPHENOL, 98+%;5-Fluoro-2-hydroxynitrobenzene;Phenol, 4-fluoro-2-nitro-;2-NITRO-4-FLUOROPHENOL
• CAS NO: 394-33-2
• Molecular Formula: C₆H₄FNO₃
• Molecular Weight: 157.1
• EINECS: 206-894-0
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 394-33-2.mol
• Article Data: 49

Chemical Properties

• Melting Point: 75-77 °C(lit.)
• Boiling Point: 234.1 °C at 760 mmHg
• Flash Point: 95.4 °C
• Appearance: yellow crystalline powder
• Density: 1.4306 (estimate)
• Vapor Pressure: 0.0353mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.76±0.14(Predicted)
• BRN: 1950412
• CAS DataBase Reference: 2-Nitro-4-fluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitro-4-fluorophenol(394-33-2)
• EPA Substance Registry System: 2-Nitro-4-fluorophenol(394-33-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 394-33-2(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystalline powder

Uses

4-Fluoro-2-nitrophenol may be used in the preparation of 5-fluoro-2-methoxyanilineand 5-fluoro-2-hydroxyaniline.

General Description

4-Fluoro-2-nitrophenol is formed during iron(III) nitrate nonahydrate activated by tungstophosphoric acid cesium salt catalyzed nitration of 4-fluorophenol.

InChI:InChI=1/C6H4FNO3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H/p-1

Upstream product

• 371-41-5 4-Fluorophenol 
• 371-40-4 4-fluoroaniline 
• 540-80-7 tert.-butylnitrite 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 446-09-3 2-bromo-5-fluoronitrobenzene 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 7697-37-2 nitric acid 
• 123871-59-0 4-fluoro-4-nitrocyclohexa-2,5-dienone 
• 119-34-6 4-amino-2-nitrophenol 
• 42864-24-4 2-cyano-3,4-dimethyl-4-nitrocyclohexa-2,5-dienyl acetate 
• 321-04-0 4-fluoro-2-nitro-phenetole 
• 445-83-0 4-fluoro-1-methoxy-2-nitrobenzene 

Downstream Products

• 387-97-3 5-fluoro-8-quinolinol 
• 334929-98-5 5-Fluoro-2-(2,2,2-trifluoroethoxy)-nitrobenzene 
• 399-97-3 2-amino-4-fluorophenol 
• 13451-78-0 5-fluorobenzo[d]oxazole-2-thiol 
• 1092496-34-8 2-[3-(4-fluoro-2-nitrophenoxy)propyl]isoindole-1,3-dione 
• 1092496-26-8 4-fluoro-2-nitro-1-propoxybenzene 
• 221347-71-3 5-fluorobenzo[d]oxazole 
• 1225014-14-1 C₁₃H₁₆FNO₅ 
• 1225014-16-3 C₁₃H₁₄FNO₇ 
• 1225014-15-2 C₁₆H₁₄FNO₅ 
• 1225014-13-0 C₁₂H₁₄FNO₅ 

Relevant articles and documents

Method for synthesizing nitro (hetero) aromatic hydrocarbon

The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.

Nitration method for aryl phenol or aryl ether derivative

The invention relates to a nitration method for an aryl phenol or aryl ether derivative. The method comprises the steps of stirring an aryl phenol or aryl ether compound, nitrate, trimethylchlorosilane (TMSCl) and a copper salt in an acetonitrile solution in air at room temperature, simultaneously, monitoring extent of reaction through a TLC dot plate, removing a solvent from a mixture by a rotaryevaporator after a substrate is consumed completely, and carrying out purification through a silica-gel column, thereby obtaining a nitroolefin derivative. Meanwhile, the selective mono-nitration orbis-nitration of the substrate can be achieved through controlling equivalent weight of the nitrate. Compared with the prior art, the nitration method disclosed by the invention has the advantages that the consumption of strong-acid substances is avoided, the reaction conditions are mild, the yield is high, the applicable range of the substrate is wide, reaction activity is free of obvious attenuation after an amplified reaction, and an excellent yield is still obtained, so that the method has an obvious industrial application value.

Room-Temperature, Water-Promoted, Radical-Coupling Reactions of Phenols with tert -Butyl Nitrite

A radical-radical cross-coupling reaction of phenols with tert -butyl nitrite has been developed with the use of water as an additive. This method allows the construction of C-N bonds under an air atmosphere at room temperature, providing the ortho -nitrated phenol derivative in moderate to good yields.