Technology Process of C18H19BrO3
There total 6 articles about C18H19BrO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
potassium tert-butylate;
In
tetrahydrofuran;
at -20 - -15 ℃;
for 0.5h;
Inert atmosphere;
Cooling with acetone-dry ice;
C17H17BrO4;
In
tetrahydrofuran;
at -15 - 20 ℃;
for 0.25h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.04.094
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -20 - -15 °C / Inert atmosphere; Cooling with acetone-dry ice
2.2: 0.25 h / -15 - 20 °C / Inert atmosphere
With
potassium tert-butylate; caesium carbonate; sodium iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.04.094
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; magnesium chloride / acetonitrile / 0.5 h / Inert atmosphere; Reflux
2.1: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -20 - -15 °C / Inert atmosphere; Cooling with acetone-dry ice
3.2: 0.25 h / -15 - 20 °C / Inert atmosphere
With
potassium tert-butylate; caesium carbonate; triethylamine; sodium iodide; magnesium chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
1.1: Casiraghi/Hoflokken ortho-formylation;
DOI:10.1016/j.tet.2011.04.094
