2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine

Base Information

Chemical Name:2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine
CAS No.:72676-85-8
Molecular Formula:C₁₇H₁₈ClN₅O₂
Molecular Weight:359.815
Hs Code.:

Synonyms:2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine

There total 5 articles about 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 72676-84-7
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

: 72676-85-8
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine

Guidance literature:: With N,N-dimethylformamide, thionyl chloride; In chloroform; for 3h; Heating;
DOI:10.1021/jm00177a025

Reference yield:

: 72676-84-7
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

: 2,4-Diamino-5-methyl-6-(2,5-dimethoxybenzyl)pyrido[2,3-]pyrimidine

: 72676-85-8
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine

Guidance literature:: With ammonium hydroxide; thionyl chloride; In N-methyl-acetamide; chloroform;

Reference yield:

: 93-02-7
2,5-dimethoxybenzaldehyde

: 72676-85-8
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / piperidine / benzene; acetic acid / 3 h / Heating

2: 89 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 1034.3 - 2068.6 Torr

3: 62 percent / diphenyl ether / 1.5 h / 195 - 230 °C

4: 40 percent / SOCl₂*DMF / CHCl₃ / 3 h / Heating

With piperidine; N,N-dimethylformamide, thionyl chloride; hydrogen; palladium on activated charcoal; In diphenylether; chloroform; acetic acid; ethyl acetate; benzene;
DOI:10.1021/jm00177a025