2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

Base Information

Chemical Name:2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine
CAS No.:72676-84-7
Molecular Formula:C₁₇H₁₉N₅O₃
Molecular Weight:341.37
Hs Code.:

Synonyms:2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

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Chemical Property of 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

There total 4 articles about 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1004-38-2
2,4,6-triaminopyrimidine

: 72676-83-6
ethyl α-acetyl-β-(2,5-dimethoxyphenyl)propionate

: 72676-84-7
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

Guidance literature:: In diphenylether; at 195 - 230 ℃; for 1.5h;
DOI:10.1021/jm00177a025

Reference yield:

: 1004-38-2
2,4,6-triaminopyrimidine

: 101-84-8
diphenylether

: 72676-83-6
ethyl α-acetyl-β-(2,5-dimethoxyphenyl)propionate

: 72676-84-7
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

Guidance literature:: In methanol; n-propanol water; ethanol; water;

Reference yield:

: 93-02-7
2,5-dimethoxybenzaldehyde

: 72676-84-7
2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / piperidine / benzene; acetic acid / 3 h / Heating

2: 89 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / 1034.3 - 2068.6 Torr

3: 62 percent / diphenyl ether / 1.5 h / 195 - 230 °C

With piperidine; hydrogen; palladium on activated charcoal; In diphenylether; acetic acid; ethyl acetate; benzene;
DOI:10.1021/jm00177a025