3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester
• CAS No.: 890120-43-1
• Molecular Formula: C₂₄H₂₁NO₇
• Molecular Weight: 435.433
• Mol file: 890120-43-1.mol

Synonyms:3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester

Chemical Property of 3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester

There total 2 articles about 3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-methoxy-benzyl)-1H-indol-3-yl]-oxo-acetic acid methyl ester (890120-63-5) + dimethyl diglycolate (7040-23-5) → 3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester (890120-43-1)

Guidance literature:

[1-(4-methoxy-benzyl)-1H-indol-3-yl]-oxo-acetic acid methyl ester; dimethyl diglycolate; With potassium tert-butylate; In benzene; for 2.5h; Heating / reflux;

With hydrogenchloride; In water; benzene;

Reference yield:

[1-(4-methoxy-benzyl)-1H-indol-3-yl]-oxo-acetic acid methyl ester (890120-63-5) + dimethyl diglycolate (7040-23-5) → 3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester (890120-43-1) + C23H19NO7

Guidance literature:

With potassium; tert-butyl alcohol; In benzene; for 2.5h; Reflux; Inert atmosphere;

DOI:10.1002/ddr.20391

Reference yield: 33.5%

3-hydroxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester (890120-43-1) + methyl iodide (74-88-4) → 3-methoxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester (890120-45-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 21h;

upstream raw materials:

[1-(4-methoxy-benzyl)-1H-indol-3-yl]-oxo-acetic acid methyl ester

dimethyl diglycolate

Downstream raw materials:

3-methoxy-4-[1-(4-methoxy-benzyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester