Technology Process of (3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate
There total 8 articles about (3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate which
guide to synthetic route it.
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synthetic route:
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1326312-22-4
(3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate
- Guidance literature:
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With
triethylamine;
at 20 ℃;
for 0.5h;
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1326312-22-4
(3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: dmap; triethylamine / dichloromethane / Reflux
2.1: acetic anhydride; hydrogen bromide; acetic acid / toluene / 1.5 h / 105 °C
3.1: potassium hydroxide / toluene; ethanol / 4 h / 20 °C
4.1: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
5.1: triethylamine / dichloromethane / 60 °C
6.1: sodium tetrahydroborate; nickel dichloride; methanol / 0.17 h / 0 °C
7.1: zinc(II) chloride / dichloromethane; methanol / 1 h / 80 °C
7.2: 1 h / 20 °C
8.1: triethylamine / 0.5 h / 20 °C
With
methanol; dmap; sodium tetrahydroborate; hydrogen bromide; acetic anhydride; silica gel; acetic acid; triethylamine; pyridinium chlorochromate; potassium hydroxide; nickel dichloride; zinc(II) chloride;
In
methanol; ethanol; dichloromethane; toluene;
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(3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(hydroxymethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate
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1326312-22-4
(3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
2.1: triethylamine / dichloromethane / 60 °C
3.1: sodium tetrahydroborate; nickel dichloride; methanol / 0.17 h / 0 °C
4.1: zinc(II) chloride / dichloromethane; methanol / 1 h / 80 °C
4.2: 1 h / 20 °C
5.1: triethylamine / 0.5 h / 20 °C
With
methanol; sodium tetrahydroborate; silica gel; triethylamine; pyridinium chlorochromate; nickel dichloride; zinc(II) chloride;
In
methanol; dichloromethane;