5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole

Base Information

Chemical Name:5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole
CAS No.:1262194-47-7
Molecular Formula:C₂₁H₂₀FN₅O
Molecular Weight:377.421
Hs Code.:

Synonyms:5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole

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Chemical Property of 5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole

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Technology Process of 5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole

There total 4 articles about 5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1262194-46-6
5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,4-triazole

: 74-88-4
methyl iodide

: 1262194-47-7
5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.06.100

Reference yield:

: 1262197-07-8
C₁₄H₁₆N₂O₃

: 1262194-47-7
5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 32 h / 130 °C / Sealed tube

2: potassium carbonate / butan-1-ol / 14 h / 150 °C

3: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydride; potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmcl.2013.06.100

Reference yield:

: 1242314-39-1
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzohydrazide

: 1262194-47-7
5-[(4-fluorophenyl)methyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / butan-1-ol / 14 h / 150 °C

2: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmcl.2013.06.100