(4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one

Base Information

• Chemical Name: (4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one
• CAS No.: 1415986-76-3
• Molecular Formula: C₃₀H₃₄N₂O₃
• Molecular Weight: 470.612

Synonyms:(4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one

Chemical Property of (4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one

There total 1 articles about (4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one (145589-03-3) + N,N-dibenzyliminium trifluoroacetate salt → (4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one (1415986-76-3)

Guidance literature:

(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one; With titanium tetrachloride; In dichloromethane; at 0 ℃; Inert atmosphere;

With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

N,N-dibenzyliminium trifluoroacetate salt; In dichloromethane; at -80 ℃; for 16h; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/cbdv.201200277

Reference yield: 77.0%

(4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one (1415986-76-3) + ethanethiol (75-08-1) → S-ethyl (2S)-2-(dibenzylamino)methyl-3-methylbutanethioate (1415986-79-6)

Guidance literature:

ethanethiol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

(4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

DOI:10.1002/cbdv.201200277

Reference yield:

(4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one (1415986-76-3) → (2S)-2-(dibenzylamino)methyl-3-methylbutanoic acid (928659-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: water; mercury(II) trifluoroacetate / tetrahydrofuran / 20 °C / Inert atmosphere

With n-butyllithium; water; mercury(II) trifluoroacetate; In tetrahydrofuran; hexane;

DOI:10.1002/cbdv.201200277

upstream raw materials:

(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one

Downstream raw materials:

S-ethyl (2S)-2-(dibenzylamino)methyl-3-methylbutanethioate

(2S)-2-(dibenzylamino)methyl-3-methylbutanoic acid

(2S)-([amino]methyl)-3-methylbutanoic acid

(2S)-2-({[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methyl)-3-methylbutanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1415986-76-3 (4R)-4-benzyl-3-[(2S)-2-(dibenzylamino)methyl-3-methylbutanoyl]-1,3-oxazolidin-2-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send