(E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

Base Information

Chemical Name:(E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal
CAS No.:121660-62-6
Molecular Formula:C₂₁H₁₇ClFNO
Molecular Weight:353.823
Hs Code.:

Synonyms:(E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

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Chemical Property of (E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

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Technology Process of (E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

There total 7 articles about (E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-prop-2-en-1-ol

: 121660-62-6
(E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/jm00105a057

Reference yield:

: 121660-10-4
[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-methanol

: 121660-62-6
(E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: tetrahydrofuran; hexane / -78 °C

3.1: p-toluenesulfonic acid / tetrahydrofuran; H₂O / 20 °C

With n-butyllithium; sodium acetate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1016/S0968-0896(01)00198-5

Reference yield:

: 121660-36-4
6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinoline-3-carbaldehyde

: 121660-62-6
(E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 °C

2.1: p-toluenesulfonic acid / tetrahydrofuran; H₂O / 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; water;
DOI:10.1016/S0968-0896(01)00198-5