(1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

Base Information

Chemical Name:(1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide
CAS No.:1357923-28-4
Molecular Formula:C₁₇H₂₅N₃O₄
Molecular Weight:335.403
Hs Code.:

Synonyms:(1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

Chemical Property:

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Technology Process of (1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

There total 1 articles about (1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 503315-74-0
(3-fluoro-4-nitrophenyl)methanol

: 1357923-26-2
C₁₀H₂₀N₂O*ClH

: 1357923-28-4
(1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 16h;
DOI:10.1021/jm3005866

Reference yield:

: 1357923-28-4
(1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

: C₂₅H₂₈ClFN₄O₂

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 60 °C

3: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

With thionyl chloride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm3005866

Reference yield:

: 1357923-28-4
(1s,4s)-4-((5-(hydroxymethyl)-2-nitrophenyl)amino)-N-isopropylcyclohexanecarboxamide

: 1357920-88-7,1388225-65-7
(E)-4-fluoro-N-(1-((1s,4s)-4-(isopropylcarbamoyl)-cyclohexyl)-6-(piperazin-1-ylmethyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 60 °C

3: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

4: acetonitrile / 16 h / 20 °C

With thionyl chloride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm3005866