{(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene

Base Information

Chemical Name:{(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene
CAS No.:129952-19-8
Molecular Formula:C₂₅H₄₆O₃Si₂
Molecular Weight:450.809
Hs Code.:

Synonyms:{(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene

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Chemical Property of {(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene

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Technology Process of {(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene

There total 7 articles about {(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 129952-18-7
(E)-(2R,3R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-8-trimethylsilanyl-oct-6-en-3-ol

: 100-39-0
benzyl bromide

: 129952-19-8
{(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 18h; 0 to 20 deg C;
DOI:10.1016/S0040-4039(00)89010-3

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 129952-19-8
{(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene

Guidance literature:: Multi-step reaction with 7 steps

2: 90 percent / DMSO, (COCl)2, NEt₃ / CH₂Cl₂ / 1.5 h / -70 °C

3: 1.) NEt₃, Bu₂BOTf / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) -78 to -40 deg C, 2 h

4: 82 percent / MeMgBr / 0.17 h / 0 °C

5: 84 percent / LiAlH₄ / diethyl ether / 3 h / 0 to 20 deg C

6: 96 percent / imidazole / CH₂Cl₂ / 18 h / 20 °C

7: 73 percent / NaH / dimethylformamide / 18 h / 0 to 20 deg C

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; methylmagnesium bromide; sodium hydride; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)89010-3

Reference yield:

: 118992-21-5
(E)-6-(trimethylsilyl)hex-4-enal

: 129952-19-8
{(E)-(R)-1-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-ethyl]-6-trimethylsilanyl-hex-4-enyloxymethyl}-benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NEt₃, Bu₂BOTf / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) -78 to -40 deg C, 2 h

2: 82 percent / MeMgBr / 0.17 h / 0 °C

3: 84 percent / LiAlH₄ / diethyl ether / 3 h / 0 to 20 deg C

4: 96 percent / imidazole / CH₂Cl₂ / 18 h / 20 °C

5: 73 percent / NaH / dimethylformamide / 18 h / 0 to 20 deg C

With 1H-imidazole; lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; methylmagnesium bromide; sodium hydride; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)89010-3