4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester

Base Information

Chemical Name:4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester
CAS No.:1630974-80-9
Molecular Formula:C₂₂H₁₅ClN₂O₅
Molecular Weight:422.824
Hs Code.:

Synonyms:4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester

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Chemical Property of 4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester

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Technology Process of 4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester

There total 7 articles about 4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1630974-74-1
2-(p-tolyl)-3-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

: 122-01-0
4-chloro-benzoyl chloride

: 1630974-80-9
4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.5012/bkcs.2014.35.5.1337

Reference yield:

: 1630974-71-8
2-(p-tolyl)-4-nitro-2,3-dihydroisoindol-1-one

: 1630974-80-9
4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile / 2.5 h / 20 °C / Inert atmosphere; Reflux

2: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triethylamine; In acetonitrile;
DOI:10.5012/bkcs.2014.35.5.1337

Reference yield:

: 59382-59-1
2-methyl-3-nitro-benzoic acid methyl ester

: 1630974-80-9
4-chlorobenzoic acid 7-nitro-3-oxo-2-(p-tolyl)-2,3-dihydro-1H-isoindol-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 26 h / 20 °C / Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / 5 h / 20 °C / Inert atmosphere

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile / 2.5 h / 20 °C / Inert atmosphere; Reflux

4: triethylamine / acetonitrile / 3 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; In tetrachloromethane; acetonitrile;
DOI:10.5012/bkcs.2014.35.5.1337