4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester

Base Information

Chemical Name:4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester
CAS No.:1346862-99-4
Molecular Formula:C₁₇H₂₂N₂O₄
Molecular Weight:318.373
Hs Code.:

Synonyms:4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester

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Chemical Property of 4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester

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Technology Process of 4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester

There total 4 articles about 4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 1204296-63-8
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid

: 1346862-99-4
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester

Guidance literature:: 4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere;

2-(N,N-dimethylamino)ethanol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere;
DOI:10.1021/ml200217u

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1346862-99-4
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / Heating; Inert atmosphere

1.2: Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide / Heating; Inert atmosphere

3.1: alkali hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux

3.2: pH 2

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

4.2: 40 °C / Inert atmosphere

With potassium tert-butylate; 1,1'-carbonyldiimidazole; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; 1.1: Vilsmeier formylation / 1.2: Vilsmeier formylation;
DOI:10.1021/ml200217u

Reference yield:

: C₁₅H₂₃N₂O₂⁽¹⁺⁾*F₆P^(1-)

: 1346862-99-4
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / Heating; Inert atmosphere

2.1: alkali hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux

2.2: pH 2

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

3.2: 40 °C / Inert atmosphere

With potassium tert-butylate; 1,1'-carbonyldiimidazole; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200217u