3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride

Base Information

• Chemical Name: 3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride
• CAS No.: 220006-54-2
• Molecular Formula: C₁₃H₁₃ClO
• Molecular Weight: 220.699
• Mol file: 220006-54-2.mol

Synonyms:3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride

Chemical Property of 3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride

There total 2 articles about 3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-(tert-butyl)phenyl)propiolic acid (220006-53-1) → 3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride (220006-54-2)

Guidance literature:

With sodium hydroxide; oxalyl dichloride; Yield given; Multistep reaction; 1.) H₂O, 2.) benzene, room temp., overnight;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2341::AID-HLCA2341>3.0.CO;2-U

Reference yield:

4-tert-Butylphenylacetylene (772-38-3) → 3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride (220006-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / BuLi / tetrahydrofuran; hexane / -40 to -20 deg C, 120 min; -20 deg C to room temp.

2: 1.) aq. NaOH, 2.) oxalyl chloride / 1.) H₂O, 2.) benzene, room temp., overnight

With sodium hydroxide; n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2341::AID-HLCA2341>3.0.CO;2-U

Reference yield: 55.0%

3-<4-(tert-butyl)phenyl>prop-2-ynoyl chloride (220006-54-2) → 3-<4-(tert-butyl)phenyl>prop-2-ynoyl azide (220006-55-3)

Guidance literature:

With pyridine; sodium azide; acetyl chloride; In diethyl ether; acetonitrile; at -5 ℃; for 4h;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2341::AID-HLCA2341>3.0.CO;2-U

upstream raw materials:

3-(4-(tert-butyl)phenyl)propiolic acid

4-tert-Butylphenylacetylene

Downstream raw materials:

3-<4-(tert-butyl)phenyl>prop-2-ynoyl azide

1-(4-tert-butyl-phenyl)-5-trimethylsilanyl-penta-1,4-diyn-3-one

1-tert-butyl-4-(3-dibromomethylene-penta-1,4-diynyl)-benzene

[5-(4-tert-butyl-phenyl)-3-dibromomethylene-penta-1,4-diynyl]-trimethyl-silane