methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

Base Information

Chemical Name:methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate
CAS No.:1142228-10-1
Molecular Formula:C₂₃H₂₅FO₄
Molecular Weight:384.448
Hs Code.:

Synonyms:methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

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Chemical Property of methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

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Technology Process of methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

There total 6 articles about methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1011531-89-7
2-(5,5-dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1 ,3 ,2-dioxaborolane

: 1142228-08-7
methyl 3-bromo-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

: 1142228-10-1
methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In water; N,N-dimethyl-formamide; at 75 ℃; for 18h; Inert atmosphere;

Reference yield:

: 4541-32-6
2,2-dimethylcyclopentanone

: 1142228-10-1
methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: potassium phenolate / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / toluene / 2 h / 50 °C / Inert atmosphere

3.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 18 h / 75 °C / Inert atmosphere

With potassium phosphate; potassium phenolate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; triphenylphosphine; In tetrahydrofuran; n-heptane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 350-29-8
3-fluoro-4-hydroxybenzoic acid

: 1142228-10-1
methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 20.5 h / 80 °C

2.1: bromine; acetic acid / dichloromethane / 20 °C / Cooling with ice

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 4 h

4.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 18 h / 75 °C / Inert atmosphere

With potassium phosphate; sulfuric acid; bromine; caesium carbonate; acetic acid; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; In dichloromethane; water; N,N-dimethyl-formamide;