Heptaethylene glycol monododecyl ether

Base Information

• Chemical Name: Heptaethylene glycol monododecyl ether
• CAS No.: 3055-97-8
• Deprecated CAS: 1422284-03-4,1629879-35-1,647835-70-9
• Molecular Formula: C26H54O8
• Molecular Weight: 494.71
• Hs Code.: 2909499000
• European Community (EC) Number: 221-283-9
• DSSTox Substance ID: DTXSID8062816
• Nikkaji Number: J205.361F
• Wikidata: Q72470379
• RXCUI: 1363566
• Mol file: 3055-97-8.mol

Synonyms:aethoxysclerol;aethoxysklerol;aetoxisclerol;alpha-Dodecyl-omega-hydroxypoly(oxy-1,2ethanediyl);atossisclerol;atoxysclerol;Brij 30;Brij-30;Brij30;dodecyl ethyleneglycol monoether;Dodecyl Ethyleneglycol Monoethers;Ether, Nonaethyleneglycol Monododecyl;Ether, Polyethylene Glycol-7-lauryl;Ether, Polyoxyethylene 9-lauryl;Ether, Polyoxyethylene Lauryl;Ether, Polyoxyethylene-4-dodecyl;Ether, Tetraethyleneglycol Lauryl;ethoxysclerol;Ethyleneglycol Monoether, Dodecyl;hydroxypolyethoxydodecane;Laureth;Laureth 1;Laureth 4;Laureth 7;laureth 9;laureth-1;laureth-4;laureth-7;laureth-9;Laureths;lauromacrogol;lauromacrogol 400;lauromacrogols;Lauryl Ether, Tetraethyleneglycol;lubrol 12A9;Lubrol PX;lubrol-PX;Monododecyl Ether, Nonaethyleneglycol;Monoether, Dodecyl Ethyleneglycol;nonaethylene glycol monododecyl ether;nonaethyleneglycol monododecyl ether;Nonaethyleneglycol Monododecyl Ethers;polidocanol;Polidocanols;Polyethylene Glycol 7 lauryl Ether;polyethylene glycol monododecyl ether;polyethylene glycol-7-lauryl ether;Polyethylene Glycol-7-lauryl Ethers;Polyoxyethylene 4 dodecyl Ether;Polyoxyethylene 9 lauryl Ether;polyoxyethylene 9-lauryl ether;Polyoxyethylene 9-lauryl Ethers;polyoxyethylene lauryl ether;Polyoxyethylene Lauryl Ethers;polyoxyethylene(4) lauryl ether;polyoxyethylene-4-dodecyl ether;polyoxyethylenedodecyl ether;Polyoxyethylenedodecyl Ethers;tetraethylene glycol dodecyl ether;tetraethyleneglycol lauryl ether;Tetraethyleneglycol Lauryl Ethers;thesit

Chemical Property of Heptaethylene glycol monododecyl ether

Chemical Property:

• Appearance/Colour: Liquid
• Vapor Pressure: 1.4E-14mmHg at 25°C
• Melting Point: 27-29 °C
• Refractive Index: 1.457
• Boiling Point: 553.945 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 288.816 °C
• PSA: 84.84000
• Density: 0.99 g/cm³
• LogP: 4.01580
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 31
• Exact Mass: 494.38186868
• Heavy Atom Count: 34
• Complexity: 347

Purity/Quality:

98%,99%, ^*data from raw suppliers

HeptaethyleneGlycolMonododecylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO
• Uses: Heptaethylene Glycol Monododecyl Ether (laureth-7) is a wetting agent also used as an emulsifier, surfactant, detergent, and solubilizer for active substances. Heptaethylene glycol monododecyl ether is a non-ionic detergent compound.

Technology Process of Heptaethylene glycol monododecyl ether

There total 9 articles about Heptaethylene glycol monododecyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

oxirane (75-21-8,99932-75-9) + 1-dodecyl alcohol (112-53-8) → heptaethylene glycol monododecyl ether (3055-97-8)

Guidance literature:

With K₁₀ clay; at 50 ℃;

DOI:10.1002/jsde.12379

Reference yield: 88.0%

tetraethylene glycol monododecyl ether (5274-68-0,9015-55-8) + C6H12O6S → heptaethylene glycol monododecyl ether (3055-97-8)

Guidance literature:

tetraethylene glycol monododecyl ether; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Inert atmosphere;

C₆H₁₂O₆S; In tetrahydrofuran; mineral oil; pH=2; Inert atmosphere;

With sulfuric acid; In tetrahydrofuran; water; mineral oil; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.molpharmaceut.7b00496

Reference yield:

oxirane (75-21-8,99932-75-9) + 2-(n-butyl)octanol (3913-02-8) → heptaethylene glycol monododecyl ether (3055-97-8)

Guidance literature:

With potassium hydroxide; at 110 - 140 ℃; for 1h; under 1500.15 Torr; Inert atmosphere;

upstream raw materials:

1-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-dodecane

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

oxirane

1-dodecyl alcohol

Downstream raw materials:

decaethylene glycol monodecyl ether

Refernces

• 1、 Hussein, Ahmed M.,Khowdiary, Manal M.. "Nonionic Isatin Surfactants: Synthesis, Quantum Chemical Calculations, ADMET and Their Antimicrobial Activities". . p. 489 - 501. Retrieved 2020/02/11.
• 2、 Yu, Zeqiong,Bo, Shaowei,Wang, Huiyuan,Li, Yu,Yang, Zhigang,Huang, Yongzhuo,Jiang, Zhong-Xing. "Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols". . p. 3473 - 3479. Retrieved 2017/10/11.