(+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate

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Chemical Name:(+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate
CAS No.:1393126-76-5
Molecular Formula:C₂₈H₃₂F₃N₃O₄
Molecular Weight:531.575
Hs Code.:

Synonyms:(+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate

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Chemical Property of (+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate

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Technology Process of (+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate

There total 8 articles about (+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1393126-75-4
(+/-)-4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzoic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1393126-76-5
(+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 4h;

Reference yield:

: (4-bromo-2,6-dimethylphenyl)hydrazine hydrochloride

: 1393126-76-5
(+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C

1.2: 5 h / 80 °C

2.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / 20 °C

4.2: pH 3

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; water; ethyl acetate; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction;

Reference yield:

: 24596-19-8
4-bromo-2,6-dimethylphenylamine

: 1393126-76-5
(+/-)-ethyl 3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

1.2: 16 h / 0 - 20 °C

2.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C

2.2: 5 h / 80 °C

3.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / 20 °C

5.2: pH 3

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h

With hydrogenchloride; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium hydroxide; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; water; ethyl acetate; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;