Technology Process of (+/-)-4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzoic acid
There total 7 articles about (+/-)-4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(+/-)-ethyl 4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzoate;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 18h;
With
citric acid;
In
water;
pH=3;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C
1.2: 5 h / 80 °C
2.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / 20 °C
4.2: pH 3
With
lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; sodium methylate; triphenylphosphine; potassium hydroxide;
tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; water; ethyl acetate;
3.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C
1.2: 16 h / 0 - 20 °C
2.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C
2.2: 5 h / 80 °C
3.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / 20 °C
5.2: pH 3
With
hydrogenchloride; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; sodium methylate; triphenylphosphine; potassium hydroxide; sodium nitrite;
tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; water; ethyl acetate;
4.1: Mitsunobu reaction;
