1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 145645-62-1
• Molecular Formula: C21H22 N2 O3 . Cl H
• Molecular Weight: 350.417
• Mol file: 145645-62-1.mol

Synonyms:3-Pyridinecarboxylicacid, 1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-1,2,5,6-tetrahydro-,monohydrochloride (9CI); NNC 05-711; NNC 711

Chemical Property of 1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.52E-12mmHg at 25°C
• Boiling Point: 541.2°C at 760 mmHg
• Flash Point: 281.1°C
• PSA: 62.13000
• LogP: 3.91220
• Storage Temp.: Desiccate at +4°C
• Solubility.: H2O: ≥10 mg/mL at 60 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

NNC 711 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: NNC 711 is an anticonvulsant agent and a selective GABA uptake inhibitor (1,2). NO-711 hydrochloride is suitable for use as γ-aminobutyric acid (GABA) transporter-1 (GAT-1) antagonists or GABA uptake inhibitor.

Technology Process of 1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE

There total 3 articles about 1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzophenone (119-61-9) → 1-(2-(((Diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid (145645-62-1)

Guidance literature:

With sodium hydroxide; In ethanol;

Reference yield:

ethyl 1-[2-[[(diphenyl)imino]oxy]ethyl]-3-(1,2,5,6-tetrahydropyridin-1-yl)carboxylate hydrochloride → 1-(2-(((Diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid (145645-62-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 2.5h;

DOI:10.1021/jm981027k

Reference yield:

→ 1-(2-(((Diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid (145645-62-1)

Guidance literature:

upstream raw materials:

benzophenone

Refernces

• 1、 Knutsen, Lars J. S.,Andersen, Knud Erik,Lau, Jesper,Lundt, Behrend F.,Henry, Rodger F.,Morton, Howard E.,N?rum, Lars,Petersen, Hans,Stephensen, Henrik,Suzdak, Peter D.,Swedberg, Michael D. B.,Thomsen, Christian,S?rensen, Per O.. "Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents". . p. 3447 - 3462. Retrieved 2007/10/03.