(R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Base Information

• Chemical Name: (R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide
• CAS No.: 223589-06-8
• Molecular Formula: C₂₁H₂₉NO₄S
• Molecular Weight: 391.532
• Mol file: 223589-06-8.mol

Synonyms:(R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Chemical Property of (R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

There total 2 articles about (R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-<(3-chloropropyl)thio>-4-methoxybenzene (19433-01-3) → (R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide (223589-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / Mortierella isabellina ATCC 42613 / Microbiological reaction

2: 0.75 h / 115 °C

With Mortierella isabellina ATCC 42613; 1: Oxidation / 2: Dehydrochlorination;

DOI:10.1023/A:1018888711071

Reference yield:

N-methylhomoveratrylamine (3490-06-0) + (R)-(+)-3-chloropropyl 4-methoxyphenyl sulfoxide (223588-83-8) → (R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide (223589-06-8)

Guidance literature:

at 115 ℃; for 0.75h;

DOI:10.1023/A:1018888711071

Reference yield: 71.0%

isobutyryl-3,4-dimethoxybenzene (14046-55-0) + (R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide (223589-06-8) → (+)-1-[1-(3,4-dimethoxyphenyl)-1-hydroxy-2-methylpropyl]-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide

Guidance literature:

(R)-(+)-3-[methyl-2-(3,4-dimethoxyphenyl)ethyl]amino 4-methoxyphenyl sulfoxide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

isobutyryl-3,4-dimethoxybenzene; In tetrahydrofuran; hexane; at -78 - -45 ℃; for 0.75h;

DOI:10.1023/A:1018888711071

upstream raw materials:

N-methylhomoveratrylamine

(R)-(+)-3-chloropropyl 4-methoxyphenyl sulfoxide

1-<(3-chloropropyl)thio>-4-methoxybenzene