14046-55-0 Usage
Description
(3,4-Dimethoxyphenyl)isopropyl ketone, also known as 1-(3,4-Dimethoxyphenyl)-2-methyl-1-propanone (Verapamil EP Impurity L), is an organic compound with potential applications in various industries. It is characterized by its unique chemical structure, which includes a 3,4-dimethoxyphenyl group and an isopropyl ketone group. This structure endows the compound with specific properties that make it suitable for use in different applications.
Uses
Used in Pharmaceutical Industry:
(3,4-Dimethoxyphenyl)isopropyl ketone is used as an inhibitor of melanogenesis for its potential to reduce growth or pigment production in melanocyte cells. This application is particularly relevant in the development of treatments for conditions related to excessive pigmentation, such as melasma or other hyperpigmentation disorders.
Used in Cosmetics Industry:
In the cosmetics industry, (3,4-Dimethoxyphenyl)isopropyl ketone may be utilized as an active ingredient in skin care products aimed at reducing the appearance of pigmentation and promoting an even skin tone. Its melanogenesis-inhibiting properties could make it a valuable addition to formulations designed to address hyperpigmentation and other related skin concerns.
Used in Research and Development:
(3,4-Dimethoxyphenyl)isopropyl ketone may also be used as a research compound in the development of new drugs and therapies targeting melanogenesis and related processes. Its unique chemical structure and properties make it a promising candidate for further investigation and potential application in the field of medicinal chemistry.
Preparation
Preparation by acylation of veratrole, with isobutyryl chloride in the presence of aluminium chloride (85%) with isobutyric acid in the presence of PPA at 60° for 2.5 h with isobutyric anhydride in acetonitrile in the presence of TiCl(OTf)3 /TfOH at r.t. for 12 h (89%).
Check Digit Verification of cas no
The CAS Registry Mumber 14046-55-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,4 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14046-55:
(7*1)+(6*4)+(5*0)+(4*4)+(3*6)+(2*5)+(1*5)=80
80 % 10 = 0
So 14046-55-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O3/c1-8(2)12(13)9-5-6-10(14-3)11(7-9)15-4/h5-8H,1-4H3
14046-55-0Relevant articles and documents
Surface control of a photoresponsive self-assembled monolayer and selective deposition of Ag Nanoparticulate Ink
Konishi, Tsubasa,Yamaguchi, Kazuo
, p. 424 - 429 (2016)
A highly hydrophobic self-assembled monolayer (SAM) with high photosensitivity to soft UV (λ = 365 nm) was formed on thermally surface-oxidized silicon wafers by a silane coupling agent bearing a 2-nitrobenzyl carbamate moiety. Very smooth SAM was obtaine
Copper-catalyzed iminohalogenation of γ, δ-unsaturated oxime esters with halide salts: Synthesis of 2-halomethyl pyrrolines
Chen, Chen,Ding, Jie,Wang, Yuebo,Shi, Xiaonan,Jiao, Dequan,Zhu, Bolin
supporting information, (2019/08/13)
A copper-catalyzed iminohalogenation of unactivated alkenes of γ, δ-unsaturated oxime esters is achieved by using readily available halide salts. Utilizing this protocol, a sequence of structurally diversiform 2-halomethyl pyrrolines are efficiently synthesized and a mechanism involving iminyl radical intermediates, which were initiated by Cu(I) species, was proposed.
Silver-promoted cascade radical cyclization of γ,δ-unsaturated oxime esters with P(O)H compounds: synthesis of phosphorylated pyrrolines
Chen, Chen,Bao, Yinwei,Zhao, Jinghui,Zhu, Bolin
, p. 14697 - 14700 (2019/12/11)
A cascade radical cyclization was realized for the first silver-promoted imino-phosphorylation of γ,δ-unsaturated oxime esters, which provided a step-economical and redox-neutral route to access a variety of phosphorylated pyrrolines in good to excellent yields. Moreover, a new bulky trivalent phosphine ligand with a pyrroline motif was obtained through a deoxidation process.
