N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide

Base Information

Chemical Name:N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide
CAS No.:1361332-06-0
Molecular Formula:C₂₈H₅₁NO₅Si
Molecular Weight:509.802
Hs Code.:

Synonyms:N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide

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Chemical Property of N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide

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Technology Process of N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide

There total 6 articles about N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1361331-91-0
(S)-N-tert-butyl-2-(methoxymethoxy)-3-(2-methylbutyl)benzamide

: 95338-04-8,110171-85-2,130659-83-5,95337-97-6
(2-((S)-oxiran-2-yl)ethoxy)(tert-butyl)dimethylsilane

: 1361332-06-0
N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide

Guidance literature:: (S)-N-tert-butyl-2-(methoxymethoxy)-3-(2-methylbutyl)benzamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at -78 - -40 ℃; for 2h; Inert atmosphere;

(2-((S)-oxiran-2-yl)ethoxy)(tert-butyl)dimethylsilane; In tetrahydrofuran; hexane; at -78 - -40 ℃; Inert atmosphere;
DOI:10.1002/anie.201106435

Reference yield:

: 68314-54-5
1-bromo-2-(methoxymethoxy)benzene

: 1361332-06-0
N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 1.5 h / 0 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 5 h / -30 - -5 °C

2.2: -5 - 20 °C

3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 2 h / -78 - -40 °C / Inert atmosphere

3.2: -78 - -40 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; magnesium; In tetrahydrofuran; diethyl ether; hexane; 1.1: Kumada coupling reaction / 1.2: Kumada coupling reaction;
DOI:10.1002/anie.201106435

Reference yield:

: 1609-86-5
Tert-butyl isocyanate

: 1361332-06-0
N-tert-butyl-6-[(R)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl]-2-(methoxymethoxy)-3-((S)-2-methylbutyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 5 h / -30 - -5 °C

1.2: -5 - 20 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 2 h / -78 - -40 °C / Inert atmosphere

2.2: -78 - -40 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane;
DOI:10.1002/anie.201106435