N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide

Base Information

Chemical Name:N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide
CAS No.:1312760-09-0
Molecular Formula:C₂₉H₂₉F₃N₆O₂
Molecular Weight:550.583
Hs Code.:

Synonyms:N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide

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Technology Process of N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide

There total 3 articles about N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 103-82-2
phenylacetic acid

: 950821-44-0
2-(2,4-difluorophenyl)-1-[4-(2-fluoro-4-amino-phenyl)-piperazin-1-yl]-3-(1H-1,2,4-triazol-1-yl)-propan-2-ol

: 1312760-09-0
N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2011.02.042

Reference yield:

: 154590-33-7
1-(2-fluoro-4-nitrophenyl)piperazine

: 1312760-09-0
N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 5 h / 80 °C

2: hydrazine hydrate / ethanol / 3.5 h / 80 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.042

Reference yield:

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1312760-09-0
N-(4-(4-[2-(2,4-difluoro-phenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluoro-phenyl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 5 h / 80 °C

2: hydrazine hydrate / ethanol / 3.5 h / 80 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.042