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86386-77-8

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  • 2-[[(2,4-Difluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole methanesulfonate Manufacturer/High quality/Best price/In stock

    Cas No: 86386-77-8

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  • High quality 1[(2,(2,4-Diflurophenyl)2-3,Epxoy Propyl]1 H, 1,2,4 Triazole Methane Sulphonat supplier in China

    Cas No: 86386-77-8

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  • Simagchem Corporation
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  • 1-[2-(2,4-Difluorophenyl)-oxiranyl]-methyl-1H-1,2,4-triazole monomethanesulfonate

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  • 2,4-Difluorophenyl) 1-(1H, 1-yl-1,2,4 Triazole-2,3-Epoxy propane methane sulfona/ CAS:86386-77-8 / raw material/ high-quality

    Cas No: 86386-77-8

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  • TIANFUCHEM--86386-77-8--2,4-Difluorophenyl) 1-(1H, 1-yl-1,2,4 Triazole-2,3-Epoxy propane methane sulfona in stock

    Cas No: 86386-77-8

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86386-77-8 Usage

General Description

The chemical "2,4-Difluorophenyl) 1-(1H, 1-yl-1,2,4 Triazole-2,3-Epoxy propane methane sulfona" seems to have combined multiple terms perhaps erroneously. Breaking it down, "2,4-Difluorophenyl" refers to the phenyl group, a crucial part in many pharmaceuticals and pigments, which is substituted by two fluorine atoms at the second and fourth positions. "1,2,4-Triazole" is a class of heterocyclic components found in a range of synthetic compounds, often used for their biological activity. They can be prepared using the Einhorn-Brunner reaction or the Pellizzari reaction. Epoxy Propane, also known as propylene oxide, is an organic compound used in the production of polyurethane plastics. Methane Sulfonic Acid is a colorless liquid with the formula CH3SO3H and is often used in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 86386-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,3,8 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 86386-77:
(7*8)+(6*6)+(5*3)+(4*8)+(3*6)+(2*7)+(1*7)=178
178 % 10 = 8
So 86386-77-8 is a valid CAS Registry Number.

86386-77-8 Well-known Company Product Price

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  • Alfa Aesar

  • (H61782)  1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate, 98%   

  • 86386-77-8

  • 1g

  • 202.0CNY

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  • Alfa Aesar

  • (H61782)  1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate, 98%   

  • 86386-77-8

  • 5g

  • 808.0CNY

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86386-77-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[[2-(2,4-difluorophenyl)oxiran-2-yl]methyl]-1,3-dihydro-1,2,4-triazole,methanesulfonic acid

1.2 Other means of identification

Product number -
Other names 2,4,6-TRIMETHOXYBENZYLAMINE HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86386-77-8 SDS

86386-77-8Relevant articles and documents

Isopropyl amino azole antifungal compound, and preparation method and application thereof

-

, (2016/10/10)

The invention relates to the technical field of medicine, and in particular, relates to a new azole alcohol antifungal compound having the following chemical structural general formula defined in the specification, and a preparation method and an application thereof, wherein R is selected from the group consisting of halogen, alkyl, nitro and cyano group. The compound has good antifungal activity on various superficial and deep fungi, has the advantages of high efficiency, low toxicity, wide antifungal spectra and the like compared with current clinical applied antifungal drugs, and can be used for preparation of antifungal drugs.

Allylamine substituted azole antifungal compound and preparation method and application thereof

-

, (2016/12/26)

The invention relates to the technical field of medicine, in particular to a novel azole-alcohol antifungal compound with a chemical structural general formula shown in the description and a preparation method and application. The chemical structural general formula is shown in the description, wherein R is selected from alkyl or halogens or nitryl or a cyano group. The compound has good antifungal activity in various superficial fungi and deep fungi. Compared with an existing antifungal drug applied in clinic, the novel azole-alcohol antifungal compound has the advantages of being efficient, low in toxicity, wide in antifungal spectrum and the like and can be used for preparing antifungal drugs.

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

Jiang, Zhigan,Gu, Julin,Wang, Chen,Wang, Shengzheng,Liu, Na,Jiang, Yan,Dong, Guoqiang,Wang, Yan,Liu, Yang,Yao, Jianzhong,Miao, Zhenyuan,Zhang, Wannian,Sheng, Chunquan

, p. 490 - 497 (2014/07/07)

Due to increasing incidence of invasive fungal infections and severe drug resistance to triazole antifungal agents, a series of novel antifungal triazoles with substituted triazole-piperidine side chains were designed and synthesized. Most of the target compounds showed good inhibitory activity against a variety of clinically important fungal pathogens. In particular, compounds 8t and 8v were highly active against Candida albicans and Cryptococcus neoformans with MIC values in the range of 0.125 μg/mL to 0.0125 μg/mL. They represent promising leads for the development of new generation of triazole antifungal agents. Molecular docking studies revealed that the target compounds interacted with CACYP51 mainly through hydrophobic and Van der Waals interactions.

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