3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid

Base Information

• Chemical Name: 3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid
• CAS No.: 130475-53-5
• Molecular Formula: C₂₂H₂₆N₄O₅S
• Molecular Weight: 458.538
• Mol file: 130475-53-5.mol

Synonyms:3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid

Chemical Property of 3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid

There total 5 articles about 3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-36-8) → 3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid (130475-53-5)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Heating;

Reference yield:

N-benzyl-trimethylammonium hydroxide (100-85-6) + 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-06-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3,4,5,7,8,9-Hexahydro-4-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]thieno[4,3,2-de]pyrido[1,2c]pyrimidine-3,5,9-trione + 3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid (130475-53-5)

Guidance literature:

With sodium hydroxide; In methanol; dichloromethane; water;

Reference yield:

methyl 3-amino-4-thiophenecarboxylate hydrochloride (39978-14-8) → 3-<3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>-2,4-dioxothieno<3,4-d>pyrimidin-1-yl>propanoic acid (130475-53-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 75 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / 2 h / Heating

4: 28 percent / 50percent aq. NaOH / methanol / 2 h / Heating

With sodium hydroxide; trimethylaluminum; N-benzyl-trimethylammonium hydroxide; In methanol; dichloromethane; chloroform; toluene;

upstream raw materials:

1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

methyl 3-amino-4-thiophenecarboxylate hydrochloride

ethyl (4-methoxycarbonyl)thiophene-3-carbamate

3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

Downstream raw materials:

4-Methoxy-benzoic acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

4-Chloro-benzoic acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

N-(4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl)-benzamide

Benzoic acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester