methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate

Base Information

Chemical Name:methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate
CAS No.:669062-09-3
Molecular Formula:C₃₁H₃₃ClN₂O₇S
Molecular Weight:613.131
Hs Code.:

Synonyms:methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate

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Chemical Property of methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate

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Technology Process of methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate

There total 9 articles about methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 830-42-2
N-allyl-4-chlorobenzenesulfonamide

: 669062-11-7
3-(2-allyloxy-4-methoxy-phenyl)-2-(3-chloromethyl-benzoylamino)-propionic acid methyl ester

: 669062-09-3
methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 20h;
DOI:10.1021/jo0352629

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 669062-09-3
methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 1.25 h / -12 - 35 °C

1.2: 47 percent / Ac₂O / 18 h / 65 °C

2.1: 89 percent / H₂SO₄; H₂O / 0.67 h / 0 °C

3.1: 94 percent / aq. KOH / 6 h / 20 °C

4.1: 67 percent / H₂ / Pd/C / methanol / 17 h / 3375.27 Torr

5.1: 98 percent / K₂CO₃ / dimethylformamide / 19 h / 20 °C

6.1: PCl₅; pyridine / CH₂Cl₂ / 0.25 h / 0 °C

6.2: 35 percent / n-PrOH; aq. HCl / 1 h / 20 °C

7.1: 81 percent / K₂CO₃ / CH₂Cl₂ / 20 h / 20 °C

8.1: 66 percent / NaH / dimethylformamide / 20 h

With pyridine; potassium hydroxide; phosphorus pentachloride; sulfuric acid; water; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0352629

Reference yield:

: 669062-13-9
5-methoxy-2-((Z)-(5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)methyl)phenyl acetate

: 669062-09-3
methyl N-(3-(N-(2-propen-1-yl)(4-chlorophenyl)sulfonamidomethyl)benzoyl)-O-methyl-2-(2-propen-1-yloxy)tyrosinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 89 percent / H₂SO₄; H₂O / 0.67 h / 0 °C

2.1: 94 percent / aq. KOH / 6 h / 20 °C

3.1: 67 percent / H₂ / Pd/C / methanol / 17 h / 3375.27 Torr

4.1: 98 percent / K₂CO₃ / dimethylformamide / 19 h / 20 °C

5.1: PCl₅; pyridine / CH₂Cl₂ / 0.25 h / 0 °C

5.2: 35 percent / n-PrOH; aq. HCl / 1 h / 20 °C

6.1: 81 percent / K₂CO₃ / CH₂Cl₂ / 20 h / 20 °C

7.1: 66 percent / NaH / dimethylformamide / 20 h

With pyridine; potassium hydroxide; phosphorus pentachloride; sulfuric acid; water; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0352629