3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole

Base Information

• Chemical Name: 3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole
• CAS No.: 1578247-84-3
• Molecular Formula: C₁₁H₁₂N₄O₃
• Molecular Weight: 248.241
• Mol file: 1578247-84-3.mol

Synonyms:3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole

Chemical Property of 3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole

There total 6 articles about 3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole-3-thiol (1578247-87-6) → 3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole (1578247-84-3)

Guidance literature:

With dihydrogen peroxide; acetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.8b00690

Reference yield: 47.0%

4-methyl-4H-[1,2,4]triazole (10570-40-8) + 4-bromo-2-ethoxy-1-nitro-benzene (57279-70-6) → 3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole (1578247-84-3)

Guidance literature:

With 2,2-dimethylbutyric acid; palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In toluene; at 140 ℃; for 18h; Darkness;

DOI:10.1021/acs.jmedchem.8b00690

Reference yield: 43.0%

3-ethoxy-N-methyl-4-nitrobenzamide + formic acid hydrazide (624-84-0) → 3-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole (1578247-84-3)

Guidance literature:

3-ethoxy-N-methyl-4-nitrobenzamide; With thionyl chloride; In 1,2-dichloro-ethane; at 90 ℃; for 3h; Microwave irradiation;

formic acid hydrazide; In N,N-dimethyl-formamide; at 110 ℃; for 1h; Microwave irradiation;

upstream raw materials:

5-(3-ethoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazole-3-thiol

3-ethoxy-4-nitrobenzohydrazide

3-ethoxy-4-nitro-benzoic acid

formic acid hydrazide

Downstream raw materials:

2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)aniline

N₂-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N₈-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

8-chloro-N-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methylpyrido[3,4-d]pyrimidin-2-amine

N-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)formamide

Refernces

• 1、 -. "N2-PHENYL-PYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE DERIVATIVES AND THEIR USE AS MPS1 INHIBITORS". Page/Page column 127. . Retrieved 2015/09/28.