methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Base Information

Chemical Name:methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
CAS No.:1352212-67-9
Molecular Formula:C₂₄H₂₇BrN₆O₃
Molecular Weight:527.421
Hs Code.:

Synonyms:methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Chemical Property of methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Technology Process of methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

There total 14 articles about methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1363637-27-7
C₁₇H₁₆BrN₅

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1352212-67-9
C₂₄H₂₇BrN₆O₃

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1002/cmdc.201400045

Reference yield:

: 1352212-75-9
(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1352212-67-9
methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 ℃; for 16h;

Reference yield:

: 1228553-33-0
[(S)-2-methyl-1-((S)-2-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)propyl]carbamic acid methyl ester

: 622392-04-5
2-bromo-5-iodo-pyrazine

: 1352212-67-9
methyl {(2S)-1-[(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; for 16h; Inert atmosphere; Reflux;