(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

Base Information

Chemical Name:(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate
CAS No.:1352212-75-9
Molecular Formula:CH₄O₃S*C₁₇H₁₆BrN₅
Molecular Weight:466.358
Hs Code.:

Synonyms:(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

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Chemical Property of (2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

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Technology Process of (2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

There total 5 articles about (2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: 1352212-71-5
tert-butyl (2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

: 1352212-75-9
(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

Guidance literature:: In ethanol; for 16h; Reflux;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1352212-75-9
(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 - 20 °C

2: ammonium acetate / xylenes / 5 h / 150 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

4: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

5: ethanol / 16 h / Reflux

With potassium phosphate; ammonium acetate; potassium acetate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; xylenes;

Reference yield:

: 1007882-04-3
(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1352212-75-9
(2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine methane sulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

3: ethanol / 16 h / Reflux

With potassium phosphate; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water;