4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol

Base Information

Chemical Name:4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol
CAS No.:107244-78-0
Molecular Formula:C₂₆H₃₂ClN₃O
Molecular Weight:438.013
Hs Code.:

Synonyms:4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol

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Chemical Property of 4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol

Chemical Property:

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Technology Process of 4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol

There total 6 articles about 4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 107244-69-9
4-Amino-2-cyclohexyl-6-diethylaminomethyl-phenol; hydrochloride

: 107244-78-0
4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol

Guidance literature:: In ethanol; for 1.5h; Heating;
DOI:10.1021/jm00388a027

Reference yield:

: 119-42-6
2-cyclohexylphenol

: 107244-78-0
4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / aq. HCl, NaNO₂ / aq. ethanol / 5 h / 0 °C

2: H₂ / Ni (Ra) / methanol / 5.5 h / 2663.3 Torr

3: methanol; tetrahydrofuran / 0.5 h / Heating

4: 59 percent / ethanol / 48 h / Heating

5: 6N aq. HCl / 1 h / Heating

6: 40 percent / ethanol / 1.5 h / Heating

With hydrogenchloride; hydrogen; sodium nitrite; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00388a027

Reference yield:

: 107244-54-2
Bicyclohexyl-3,6-diene-2,5-dione 5-oxime

: 107244-78-0
4-(7-Chloro-quinolin-4-ylamino)-2-cyclohexyl-6-diethylaminomethyl-phenol

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Ni (Ra) / methanol / 5.5 h / 2663.3 Torr

2: methanol; tetrahydrofuran / 0.5 h / Heating

3: 59 percent / ethanol / 48 h / Heating

4: 6N aq. HCl / 1 h / Heating

5: 40 percent / ethanol / 1.5 h / Heating

With hydrogenchloride; hydrogen; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00388a027