Technology Process of (N-benzoyl-2'-deoxy-2',2'-difluoro-3-acetyl-5'-monophosphate-1-dodecylthio-2-decyloxypropyl)cytidine
There total 11 articles about (N-benzoyl-2'-deoxy-2',2'-difluoro-3-acetyl-5'-monophosphate-1-dodecylthio-2-decyloxypropyl)cytidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; 2,4,6-triisopropylphenylsulfonyl chloride;
at 40 - 50 ℃;
for 24h;
DOI:10.1021/jm020571x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 63.5 percent / pyridine / 7 h / 70 - 72 °C
2.1: NaH / tetrahydrofuran / cooling
2.2: 57.5 percent / tetrahydrofuran / 14 h / 0 - 68 °C
3.1: 80 percent / p-TsOH / CH2Cl2; methanol / 24 h / 20 °C
4.1: POCl3; pyridine / tetrahydrofuran / 5 h
5.1: 37 percent / 2,4,6-triisopropylbenzenesulfonyl chloride; pyridine / 24 h / 40 - 50 °C
With
pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; sodium hydride; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm020571x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: KOH / ethanol / 0.5 h / 20 °C
1.2: 67.2 percent / ethanol / 24 h
2.1: 63.5 percent / pyridine / 7 h / 70 - 72 °C
3.1: NaH / tetrahydrofuran / cooling
3.2: 57.5 percent / tetrahydrofuran / 14 h / 0 - 68 °C
4.1: 80 percent / p-TsOH / CH2Cl2; methanol / 24 h / 20 °C
5.1: POCl3; pyridine / tetrahydrofuran / 5 h
6.1: 37 percent / 2,4,6-triisopropylbenzenesulfonyl chloride; pyridine / 24 h / 40 - 50 °C
With
pyridine; potassium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; sodium hydride; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm020571x
