18023-86-4Relevant academic research and scientific papers
Nucleoside Conjugates. 13. Synthesis and Antitumor Activity of 1-β-D-Arabinofuranosylcytosine Conjugates of Thioether Lipids with Improved Water Solubility
Hong, Chung Il,Nechaev, Alexander,Kirisits, Alan J.,Vig, Rakesh,West, Charles R.
, p. 1785 - 1790 (1993)
A series of ara-CDP-rac-1-S-alkyl-2-O-acyl-1-thioglycerols (3-12), analogues of highly active Cytoros (1), was prepared, and solubility, lipophilicity, and structure-activity relationships of these conjugates were investigated.The conjugates with sn-1 alk
Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect
Sevrain, Charlotte M.,Fontaine, Delphine,Bauduin, Alicia,Guéguinou, Maxime,Zhang, Bei Li,Chant?me, Aurélie,Mahéo, Karine,Pasqualin, C?me,Maupoil, Véronique,Couthon, Hélène,Vandier, Christophe,Jaffrès, Paul-Alain
supporting information, p. 2753 - 2766 (2021/04/07)
The modulation of SK3 ion channels can be efficiently and selectively achieved by using the amphiphilic compound Ohmline (a glyco-glycero-ether-lipid). We report herein a series of Ohmline analogues featuring the replacement of one ether function by a thi
ANTIVIRAL COMPOUNDS AND COMPOSITIONS
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, (2008/12/08)
Described herein are compounds useful in the treatment of viral diseases, compositions comprising them and methods of using them. The compounds comprise a nucleoside or nucleoside analog linked, commonly through a phosphate group to one of a selected grou
Synthesis and cytotoxic activity of two novel 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine and cytosine arabinoside
Alexander, Richard L.,Morris-Natschke, Susan L.,Ishaq, Khalid S.,Fleming, Ronald A.,Kucera, Gregory L.
, p. 4205 - 4208 (2007/10/03)
Cytosine arabinoside (ara-C) and gemcitabine (dFdC) are two standard chemotherapy drugs used in the treatment of patients with various cancers. To alter the pharmacokinetic and pharmacodynamic properties of these molecules, we conjugated a synthetic phosp
A comparative study of the liquid-crystalline behavior of three homologous series of 1,2-propanediol derivatives
Doren, Henk A. van,Geest, Ralph van der,Kellogg, Richard M.,Wynberg, Hans
, p. 197 - 203 (2007/10/02)
Homologous series (R = n-hexyl to n-tetradecyl) of 3-(alkylamino)-, 3-(alkylthio)- and 3-alkoxy-1,2-propanediols have been synthesized and their thermal behavior studied by thermomicroscopy and differential-scanning calorimetry.The occurence of liquid-crystalline behavior was found to be strongly dependent on both the alkyl-chain length and the hetero-atom that links the alkyl chain to the 1,2-propanediol moiety. No thermotropic liquid-crystalline behavior could be observed for 3-alkoxy-1,2-propanediols; 3-(heptylamino)- through 3-(nonylamino)-1,2-propanediol exhibit a transient smectic A phase on supercooling of the isotropic liquid, whereas 3-(hexylthio)-1,2-propanediol through 3-(nonylthio)-1,2-propanediol form smectic phases that are quite stable.Although the thermal behavior in the pure form differs considerably, all three classes of compounds are capable of lyotropic mesophase formation in the presence of water.
Preparation of thioethers
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, (2008/06/13)
Thioethers may be prepared by reacting a thiol, such as thiophenol, with an alcohol (having electron donor groups in the alpha or beta position to its hydroxyl group) such as phenyl-1-hydroxy-phenethylsulfide. Reaction is carried out in the presence of a
Hindered hydroxyphenylalkanoates of substituted vicinal glycols
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, (2008/06/13)
The compounds are esters having the formula EQU1 wherein R1 is alkyl, cycloalkyl, alkylthioethyl or alkylpolyoxyalkylene, Z is oxygen or sulfur, R2 is the group SPC1 R3 is hydrogen, alkyl, cycloalkyl, or α-methylbenzyl, R
